Česko-slovenská pediatrie, 2023 (vol. 78), Suppl.3
Current view on the diagnostics of growth hormone deficiency in childhood and adolescenceComprehensive Report
Lukáš Plachý, Klára Maratová, Karolína Veselá, Jan Lebl, Štěpánka Průhová
Čes-slov Pediat 2023, 78(90):5-10 | DOI: 10.55095/CSPediatrie2023/056 
Optimal growth hormone (GH) production, secretion and function are essential for physiological human growth. Relevant assessment of growth hormone deficiency (GHD) is crucial for an early initiation of GH substitution aiming to improve body height and to prevent hypoglycemia and other consequences of GHD. However, even 60 years after the launch of first GH laboratory assay, diagnosis of GHD still faces technical and interpretational problems. GH stimulation tests are considered the golden standard to diagnose GHD, however their specificity is low, and therefore frequently generating false pathologic results. Therefore, diagnosis of GHD requires a complex...
Anorexia nervosa from an endocrinologist's point of viewComprehensive Report
Dana Novotná, Barbora Móriová
Čes-slov Pediat 2023, 78(90):11-16 | DOI: 10.55095/CSPediatrie2023/060
Anorexia nervosa is a complex psychiatric-metabolic-endocrine disease that has the highest mortality rate among psychiatric diseases. Almost all organs and systems are altered by this disease. Changes in the endocrine system mostly represent the body's adaptation to starvation, an d after regaining the necessary weight and fat mass, they are spontaneously adjusted. However, it does not apply to all changes. There is a disorder of the hypothalamic-pituitary axis with manifestations of hypogonadotropic hypogonadism, hypercortisolemia, resistance to growth hormone, thyroid dysfunction , hyponatremia and hypooxytocinemia. The production of antidiuretic...
Multiple endocrine neoplasia in childhood
Renata Pomahačová, Petra Paterová, Eva Nykodýmová, Petr Polák, Josef Sýkora
Čes-slov Pediat 2023, 78(90):17-21 | DOI: 10.55095/CSPediatrie2023/057
Multiple endocrine neoplasia syndromes (MEN syndromes) are rare autosomal dominantly inherited diseases with the occurence of tumors of two or more endocrine glands, with possible manifestation in early childhood. A late diagnosis of MEN syndrome can be fatal for an individual. Early identification of at-risk individuals is therefore crucial for the prevention and treatment of potentially life-threatening endocrine and non-endocrine neoplasias. MEN 2B syndrome has the most serious prognosis due to highly aggressive medullary thyroid carcinoma with early postnatal development and a high prevalence of de novo mutations. Knowledge of the non-endocrine...
Adult height in children born small for gestational age (SGA) with persistent short stature (SGA-SS). Growth hormone treatment outcomes from data of the Czech countrywide REPAR database
Ledjona Toni, Aneta Kodytková, Lukáš Plachý, Barbora Jírová, Irena Aldhoon Hainerová, Darina Aleksijević, Jana Černá, Marcela Dvořáková, Eva El-Lababidi, Božena Kalvachová, Kamila Kocourková, Ivana Kotvalová, Olga Magnová, Dana Novotná, Barbora Obermannová, Renata Pomahačová, Štěpánka Průhová, Ondřej Souček, Jiří Strnadel, Lucie Šíchová, Jaroslav Škvor, Marta Šnajderová, Zdeněk Šumník, Jiřina Zapletalová, Jiří Šilar, Stanislava Koloušková, Jan Lebl
Čes-slov Pediat 2023, 78(90):22-29 | DOI: 10.55095/CSPediatrie2023/059
Pubertal growth in children born small for gestational age (SGA) with persistent short stature (SGA-SS). Growth hormone treatment outcomes from data of the Czech countywide REPAR database
Aneta Kodytková, Ledjona Toni, Lukáš Plachý, Barbora Jírová, Irena Aldhoon Hainerová, Darina Aleksijević, Jana Černá, Marcela Dvořáková, Eva El-Lababidi, Božena Kalvachová, Kamila Kocourková, Ivana Kotvalová, Olga Magnová, Dana Novotná, Barbora Obermannová, Renata Pomahačová, Štěpánka Průhová, Ondřej Souček, Jiří Strnadel, Lucie Šíchová, Jaroslav Škvor, Marta Šnajderová, Zdeněk Šumník, Jiřina Zapletalová, Jiří Šilar, Stanislava Koloušková, Jan Lebl
Čes-slov Pediat 2023, 78(90):30-36 | DOI: 10.55095/CSPediatrie2023/058