Česko-slovenská pediatrie, 2022 (vol. 77), issue 5
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Čes-slov Pediat 2022, 77(5):259 
Století profesora Hrodka v dětské hematologii a onkologiiEditorial
Jan Starý
Čes-slov Pediat 2022, 77(5):263
New therapeutic modalities in the treatment of childhood acute lymphoblastic leukemiaComprehensive Report
Lucie Šrámková
Čes-slov Pediat 2022, 77(5):265-271 | DOI: 10.55095/CSPediatrie2022/042
Acute lymphoblastic leukemia (ALL) in children is a disease with a good chance of cure on current modern treatment protocols. Nevertheless, 10-15 % of children experience a relapse of the disease, some of them are already resistant to chemotherapy and require the use of additional treatment modalities. Of these new treatments, immunotherapy and other targeted drugs are already being used in curren t clinical practice, which have a very good effect even in significantly pre-treated patients and are gradually changing the concept of ALL treatment.
Hodgkin lymphoma - history and current approachComprehensive Report
Michaela Čepelová
Čes-slov Pediat 2022, 77(5):272-275 | DOI: 10.55095/CSPediatrie2022/043
Hodgkin lymphoma is systemic lymphoproliferative disorder diagnosed mainly in older children and adolescents, which accounts for about 10% of all lymphomas. Over the past century, Hodgkin lymphoma has transformed from a fatal disease to one of the most curable cancers with estimated 5 year survival rates exceeding 95%. Current treatment strategies are aimed at identifying the optimal balance between maintaining overall survival and avoidance of the late effects of treatment with significant decrease in quality of life.
Hematopoietic stem cell transplantation in children with inborn errors of metabolism and malignant infantile osteopetrosisOriginal Papers
Renata Formánková, Petr Říha, Petra Keslová, Pavel Ješina, Tomáš Honzík, Martin Magner, Jan Starý, Petr Sedláček, Jiří Zeman
Čes-slov Pediat 2022, 77(5):276-283 | DOI: 10.55095/CSPediatrie2022/044
Objective: Evaluation of the results of hematopoietic stem cell transplantation (HSCT) in children with inborn errors of metabolism (IEM) and malignant infantile osteopetrosis (MIOP) in the Czech Republic from the beginning of the transplant programme in 1989 to the present. Methods: In the period 1/1993 to 12/2021 a total of 31 allogeneic HSCTs were performed at the University Hospital Motol in 22 patients with IEM and 5 patients with MIOP. Patients were transplanted from HLA identical sibling (MSD), matched unrelated donor (MUD) or mismatched family donor (MMFD). The source of stem cells was bone marrow (BM), peripheral blood stem cells (PBSC) or...
Algorithm for recognition a seriously ill childPediatrické postupy v praxi
Eva Klásková, Jan David
Čes-slov Pediat 2022, 77(5):284-286 | DOI: 10.55095/CSPediatrie2022/045
Rapid assessment of the severity of the condition of an acutely ill or injured child is essential for early diagnosis and initiation of appropriate treatment. This article addresses the issue of first contact with such a sick child and offers one of the clinically validated algorithms suitable for assessing the severity of the condition - the Paediatric Assessment Triangle.
Severe congenital bleeding disorders manifesting in the neonatal period - case reportsCase Histories
Eva Jadvidžáková, Lucie Šrámková, Vladimír Komrska, Jan Starý, Ester Zápotocká
Čes-slov Pediat 2022, 77(5):287-292 | DOI: 10.55095/CSPediatrie2022/046
Congenital bleeding disorders are rare diseases. In case of a positive family history, especially in hemophilia, it is very important to prepare a plan for the birth of a child, taking into account an increased risk of bleeding. After birth of such a child, cooperation with a hematologist is key in performing necessary laboratory tests and other examinations. In a number of cases, however, the family history is silent, and the suspicion of a congenital bleeding disease arises only in the presence of bleeding associated with invasive procedures or, for example, intracranial bleed. In such case, rapid diagnosis is necessary, taking into account possible...
Jaterní infantilní hemangioendoteliomCase Histories
Michal Unzeitig, Michal Hladík, Viera Bajčiová, Jarmila Skotáková, Jiří Tůma, Marta Ježová, Hubert Mottl
Čes-slov Pediat 2022, 77(5):293-296 | DOI: 10.55095/CSPediatrie2022/047
Infantile hepatic hemangioendothelioma (IHH) is a rare, benign vascular tumor that originates from mesenchymal tissue in the liver. Although IHH is benign, it may develop life-threatening complications. We describe a 5-week-old female with a tumorous mass in the right hepatic lobe. Imaging methods pointed to an IHH diagnosis, but we could not rule out hepatoblastoma. Due to the risk of life-threat ening complications, the tumor was surgically removed. Histological analysis confirmed the diagnosis of IHH.
New possibilities of echocardiography in the diagnosis of the subclinical form of cardiotoxicity as a consequence of the treatment of children's oncological diseasesComprehensive Report
Miroslava Burešová
Čes-slov Pediat 2022, 77(5):297-302 | DOI: 10.55095/CSPediatrie2022/048
Cancer in children is the second most common cause of death after injuries. The dramatic progress achieved in the treatment of cancer in children also brings with it the clinical problem of maximizing the benefit of anticancer therapy and at the same time eliminating the late consequences as much as possible. Cardiotoxicity is a very serious side effect of cancer treatment. The method of choice fo r its detection is echocardiographic examination of the heart. In clinical practice, conventional echocardiographic modalities, such as the measurement of the ejection fraction by the Teichholz method, are still widely used to evaluate left ventricular systolic...
Hemorrhagic disease of the newborn caused by vitamin K deficiencyKapitoly k atestaci z pediatrie
Veronika Fiamoli, Jan Blatný
Čes-slov Pediat 2022, 77(5):303-305 | DOI: 10.55095/CSPediatrie2022/049
Hemorrhagic disease of a newborn is manifested by unexpected bleeding mostly in otherwise healthy newborns and infants and is caused by vitamin K deficiency, which leads to insufficient activity of vitamin K-dependent coagulation factors. The cause is the low level of vitamin K in breast milk and the insufficient synthesis of vitamin K by the neonatal bifid intestinal microflora. There are three f orms of this disease, early-onset (0-24 hours), classic (2-7 days) and late-onset (2-12 weeks). Risk of severe intracranial bleeding is typical for the early and late forms, with up to 50% mortality in the late form. The diagnostic standard is the examination...
Disseminated intravascular coagulation in childrenKapitoly k atestaci z pediatrie
Pavel Mazánek, Jan Blatný
Čes-slov Pediat 2022, 77(5):306-309 | DOI: 10.55095/CSPediatrie2022/050
Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by excessive systemic activation of coagulation, resulting in both hemorrhage and thrombosis. DIC can progress rapidly into life-threatening multiorgan failure. The diagnosis of overt DIC is based upon a combination of clinical findings and abnormal coagulation studies. The most important principle in managing a child with DIC is to identify and treat the underlying cause. DIC supportive therapy is focused on replacement of consumpted platelets and clotting factors.
Inherited coagulation disordersKapitoly k atestaci z pediatrie
Jan Máchal, Ondřej Zapletal, Jan Blatný
Čes-slov Pediat 2022, 77(5):310-313 | DOI: 10.55095/CSPediatrie2022/051
Blood coagulation disorders are relatively rare diseases with varying degrees of clinical severity, which mainly depends on the type of missing coagulation factor and its residual activity in a particular patient. This educational article in general summarised respective coagulation disorders with an emphasis on hemophilia and von Willebrand's disease. Their etiopathogenesis, clinical picture, diagnosis, treatment and its complications and prognosis is outlined.
Historický rozhovor s legendou - prof. MUDr. Otto Hrodek, DrSc. (1922–2022)Personal News
Jan Lebl
Čes-slov Pediat 2022, 77(5):314
Pediatrická poezie - České moře
Jiří Žáček
Čes-slov Pediat 2022, 77(5):315