Česko-slovenská pediatrie, 2024 (vol. 79), Suppl.3
Cryptorchidism: New insights into etiology and prognosisShort News
Jiřina Zapletalová, Kristina Holotová, Jan Lebl
Čes-slov Pediat 2024, 79(89):S7-S10 | DOI: 10.55095/CSPediatrie2024/051 
Undescended testicles are among the most common congenital abnormalities of the urogenital tract in boys, with a prevalence in full-term newborns between 1.5% and 9.0%, in premature boys around 30%. Of these, approximately 90% have unilateral and 10% bilateral testicular retention. Bilateral cryptorchidism deserves special attention. Majority of the standard procedures for testicular retention were proposed by societies of pediatric urologists, with just marginal or absent participation of pediatric endocrinologists. Anyway, bilateral testicular retention is recently becoming a key endocrine symptom pointing towards a serious complex health problem...
A patient with different sex development (DSD)
Jana Křenek Malíková, Jan Lebl, Marta Šnajderová, Jiřina Zapletalová
Čes-slov Pediat 2024, 79(89):S11-S19 | DOI: 10.55095/CSPediatrie2024/052
Long-acting growth hormone – the first year real-life experienceOriginal Papers
Jan Lebl, Irena Aldhoon Hainerová, Jana Černá, Eva El-Labibidi, Stanislava Koloušková, Ivana Kotvalová, Olga Magnová, Dana Novotná, Barbora Obermannová, Renata Pomahačová, Štěpánka Průhová, Ondřej Souček, Jiří Strnadel, Marta Šnajderová, Zdeněk Šumník, Jiřina Zapletalová
Čes-slov Pediat 2024, 79(89):S20-S24 | DOI: 10.55095/CSPediatrie2024/053
Somatrogon (Ngenla®) is the first long-acting growth hormone marketed in the Czech Republic. It is administered subcutaneously once weekly and is approved for use in growth hormone deficient patients aged from 3 to 18 years. The treatment costs are similar to daily growth hormone and a full reimbursement is guaranteed in centers for growth hormone therapy. Within 2023, the first year of a full availability of somatrogon, treatment was initiated in 166 pediatric patients. Of these, 106 (64%) were transferred from daily injections, and 60 (36%) were newly initiated. Children with newly initiated treatment were aged 7.2 years (median; range 3.0-14.0),...
Pseudohypoparathyroidism type Ia and pseudopseudohypoparathyroidismOriginal Papers
Renata Pomahačová, Petra Paterová, Eva Nykodýmová, Petr Polák, Josef Sýkora
Čes-slov Pediat 2024, 79(89):S25-S29 | DOI: 10.55095/CSPediatrie2024/054
Pseudohypoparathyroidism type Ia (PHP Ia) and pseudopseudohypoparathyroidism (PPHP) are rare autosomal dominantly inherited diseases caused by a heterozygous inactivating mutation of the GNAS1 gene encoding the stimulatory α-subunit of the G protein. The development of these diseases is related to genomic imprinting. Patients with PHP Ia have symptoms of Albright hereditary osteodystrophy (AHO) and hormone resistance to thyroid-stimulating hormone (TSH) and parathyroid hormone (PTH). Patients with PPHP have symptoms of AHO without hormone resistance. Typical symptoms of AHO in PHP Ia are early onset of obesity in infancy and subcutaneous calcifications....
An unusual cause of hyperthyroidism in a teenage girlCase Histories
Ondřej Veselý
Čes-slov Pediat 2024, 79(89):S30-S34 | DOI: 10.55095/CSPediatrie2024/040
Subacute thyroiditis is an uncommon cause of hyperthyroidism, particularly in children and adolescents. The etiopathogenesis remains unclear; however, current evidence suggests that a viral trigger leads to destructive thyroiditis in patients with a specific genetic predisposition. We present the case of a 14-year-old girl who experienced neck pain for 10 days, accompanied by fever, nervousness, sweating, and tachycardia. Laboratory tests revealed elevated levels of free thyroxine and free triiodothyronine, suppressed thyroid stimulating hormone (TSH), leukocytosis, an increased erythrocyte sedimentation rate, and high C-reactive protein. Thyroid antibodies,...
Growth charts in Czech pediatric practiceComprehensive Report
Jana Vignerová, Petr Sedlak, Markéta Paulová, Jitka Riedlová, Marek Brabec, Bohuslav Procházka
Čes-slov Pediat 2024, 79(89):S35-S40 | DOI: 10.55095/CSPediatrie2024/050
The growth charts for the Czech pediatric population are constructed on the basis of extensive Nation-wide anthropological surveys of children and youth aged birth to 18 years (NAS). The BMI and weight-for-height charts are constructed on the basis of NAS 1991 data. Growth charts for other parameters (body length, body height, head circumference, left arm circumference, abdominal and gluteal circumferences as well as abdominal circumference-for-height) are based on data from 2001. Multiple nationwide surveys allowed describing the long-term growth trends of the Czech population (increasing average body height, shift of adiposity rebound and mean age...