Čes-slov Pediat 2023, 78(90):11-16 | DOI: 10.55095/CSPediatrie2023/060

Anorexia nervosa from an endocrinologist's point of viewComprehensive Report

Dana Novotná¹, Barbora Móriová²

¹ Pediatrická klinika, Fakultní nemocnice Brno a Masarykova univerzita

² Psychiatrická klinika, Fakultní nemocnice Brno a Masarykova univerzita

Anorexia nervosa is a complex psychiatric-metabolic-endocrine disease that has the highest mortality rate among psychiatric diseases. Almost all organs and systems are altered by this disease. Changes in the endocrine system mostly represent the body's adaptation to starvation, an

d after regaining the necessary weight and fat mass, they are spontaneously adjusted. However, it does not apply to all changes. There is a disorder of the hypothalamic-pituitary axis with manifestations of hypogonadotropic hypogonadism, hypercortisolemia, resistance to growth hormone, thyroid dysfunction

, hyponatremia and hypooxytocinemia. The production of antidiuretic hormone can also be altered, and a bone metabolism disorder can be diagnosed relatively early and often persists even after recovering fro

m anorexia nervosa. Recently, changes in the intestinal microbiome, lipid metabolism, cytokine production disorders with the development of autoimmunity, and immune function disorders have also been described.

Keywords: anorexia nervosa, osteoporosis, hypothalamic dysfunction, euthyroid sick syndrome, food intake regulation

Accepted: November 22, 2023; Published: January 31, 2024  Show citation