JOURNAL OF THE CZECH PEDIATRIC SOCIETY AND THE SLOVAK PEDIATRIC SOCIETY

Čes-slov Pediat 2024, 79(2):108-114 | DOI: 10.55095/CSPediatrie2024/007

Cardiovascular and metabolic complications of childhood obesity

Jana Křenek Malíková1, Jana Čepová2, Tereza Doušová1, Marianna Durilová1, Patrik Konopásek1, Zdeněk Šumník1, Jan Lebl1
1 Pediatrická klinika, 2. lékařská fakulta, Univerzita Karlova a Fakultní nemocnice v Motole, Praha
2 Ústav lékařské chemie a klinické biochemie, 2. lékařská fakulta, Univerzita Karlova a Fakultní nemocnice v Motole, Praha

Obesity is a very serious chronic disease with accumulation of body fat. Structural and cellular changes in adipose tissue in obese individuals affect its secretory and metabolic activity with the production of several

adipokines, lipokines or other factors leading to a mild chronic inflammatory response, impaired glucose and lipid metabolism. Obesity is thus associated with comorbidities such as hypertension, type 2 diabetes, dyslipidemia, hepatic steatosis, hyperuricemia, obstructive sleep apnoea syndrome and increased cancer risk.

Musculoskeletal and psychosocial complications also play a very important role.

As the prevalence of obesity increases, so does the prevalence of these comorbidities, which reduce quality of life. The care of patients with obesity is therefore a very complex process. In addition to efforts to reduce weight by non-pharmacological, pharmacological, or surgical treatment, early detection and treatment of these complications is also important.

Keywords: obesity, hypertension, type 2 diabetes, dyslipidemia, hyperuricemia, obstructive sleep apnea syndrome, steatotic liver disease associated with metabolic dysfunction

Accepted: December 21, 2023; Published: April 1, 2024  Show citation

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Křenek Malíková J, Čepová J, Doušová T, Durilová M, Konopásek P, Šumník Z, Lebl J. Cardiovascular and metabolic complications of childhood obesity. Ces-slov Pediat. 2024;79(2):108-114. doi: 10.55095/CSPediatrie2024/007.
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