JOURNAL OF THE CZECH PEDIATRIC SOCIETY AND THE SLOVAK PEDIATRIC SOCIETY

Čes-slov Pediat 2024, 79(2):77-80 | DOI: 10.55095/CSPediatrie2024/016

Vitamin D and immunity

Vendula Látalová, František Kopřiva, Denis Dvořák, Eva Karásková
Dětská klinika, Lékařská fakulta, Univerzita Palackého v Olomouci a FN Olomouc

Vitamin D is associated primarily with calcium-phosphate metabolism. However, in recent years we have many studies demontrating its significant immunoregulatory effect, both on innate and adaptive immunity. Vitamin D is important in protection against pathogenic microorganisms and in maintaining immunotolerance, and its deficiency is assumed to be associated with infections, autoimmune or cancer d iseases.

Keywords: vitamin D, 1,25(OH)2D, calcitriol, innate immunity, adaptive immunity, autoimmunity, infection

Accepted: February 8, 2024; Published: April 1, 2024  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Látalová V, Kopřiva F, Dvořák D, Karásková E. Vitamin D and immunity. Ces-slov Pediat. 2024;79(2):77-80. doi: 10.55095/CSPediatrie2024/016.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357(3): 266-281. Go to original source... Go to PubMed...
    2. Czaja AJ, Montano-Loza AJ. Evolving role of vitamin D in immune-mediated disease and its implications in autoimmune hepatitis. Dig Dis Sci 2019; 64(2): 324-344. Go to original source... Go to PubMed...
    3. Rosen Y, Daich J, Soliman I, et al. Vitamin D and autoimmunity. Scand J Rheumatol 2016; 45(6): 439-447. Go to original source... Go to PubMed...
    4. Bikle D. Nonclassic actions of vitamin D. J Clin Endocrinol Metab 2009; 94(1): 26-34. Go to original source... Go to PubMed...
    5. Hewison M, et al. Differential regulation of vitamin D receptor and its ligand in human monocyte-derived dendritic cells. J Immunol 2003; 170(11): 5382-5390. Go to original source... Go to PubMed...
    6. Norman AW. From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. Am J Clin Nutr 2008; 88(2). Go to original source... Go to PubMed...
    7. Veldman CM, Cantorna MT, DeLuca HF. Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system. Arch Biochem Biophys 2000; 374(2): 334-338. Go to original source... Go to PubMed...
    8. Baeke F, et al. Human T lymphocytes are direct targets of 1,25-dihydroxyvitamin D3 in the immune systém. J Steroid Biochem Mol Biol 2010; 121(1-2): 221-227. Go to original source... Go to PubMed...
    9. Trinchieri G, Sher A. Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol 2007; 7(3): 179-190. Go to original source... Go to PubMed...
    10. Liu PT, Stenger S, Tang DH, Modlin RL. Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin. J Immunol 2007; 179(4): 2060-2063. Go to original source... Go to PubMed...
    11. Barlow PG, et al. Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37, PLoS One 2011; 6(10). Go to original source... Go to PubMed...
    12. Currie SM, et al. The human cathelicidin LL-37 has antiviral activity against respiratory syncytial virus. PLoS One 2013; 8(8). Go to original source... Go to PubMed...
    13. Sharma OP. Hypercalcemia in granulomatous disorders: a clinical review. Curr Opin Pulm Med 2000; 6(5): 442-447. Go to original source... Go to PubMed...
    14. Dickie LJ, Church LD, Coulthard LR. Vitamin D3 down-regulates intracellular Toll-like receptor 9 expression and Toll-like receptor 9-induced IL-6 production in human monocytes, Rheumatology (Oxford) 2010; 49(8): 1466-1471. Go to original source... Go to PubMed...
    15. Széles L, et al. 1,25-dihydroxyvitamin D3 is an autonomous regulator of the transcriptional changes leading to a tolerogenic dendritic cell phenotype. J Immunol 2009; 182(4): 2074-2083. Go to original source... Go to PubMed...
    16. Sîrbe C, Rednic S, Grama A, Pop TL. An update on the effects of vitamin D on the immune system and autoimmune diseases. Int J Mol Sci 2022; 23(17). Go to original source... Go to PubMed...
    17. Van Halteren AGS, Tysma OM, Van Etten E, et al. 1alpha,25-dihydroxyvitamin D3 or analogue treated dendritic cells modulate human autoreactive T cells via the selective induction of apoptosis, J Autoimmun 2004; 23(3): 233-239. Go to original source... Go to PubMed...
    18. Baeke F, Takiishi T, Korf H, et al. Vitamin D: modulator of the immune system. Curr Opin Pharmacol 2010; 10(4): 482-496. Go to original source... Go to PubMed...
    19. Hewison M. An update on vitamin D and human immunity. Clin Endocrinol (Oxf) 2012; 76(3): 315-325. Go to original source... Go to PubMed...
    20. Mahon BD, Wittke A, Weaver V, Cantorna MT. The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells. J Cell Biochem 2003; 89(5): 922-932. Go to original source... Go to PubMed...
    21. Jeffery LE, et al. 1,25-dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J Immunol 2009; 183(9): 5458-5467. Go to original source... Go to PubMed...
    22. Skrobot A, Demkow U, Wachowska M. Immunomodulatory role of vitamin D: a review. Adv Exp Med Biol 2018; 1108: 13-23. Go to original source... Go to PubMed...
    23. Chen S, Sims GP, Chen XX, et al. Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. J Immunol 2007; 179(3): 1634-1647. Go to original source... Go to PubMed...
    24. Heine G, et al. 1,25-dihydroxyvitamin D(3) promotes IL-10 production in human B cells. Eur J Immunol 2008; 38(8): 2210-2218. Go to original source... Go to PubMed...
    25. Pludowski P, et al. Clinical practice in the prevention, diagnosis and treatment of vitamin D deficiency: a Central and Eastern European expert consensus statement. Nutrients 2022; 14(7). Go to original source... Go to PubMed...
    26. Holick MF, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011; 96(7): 1911-1930. Go to original source... Go to PubMed...
    27. Bronský J, et al. Doporučený postup České pediatrické společnosti a Odborné společnosti praktických dětských lékařů ČLS JEP pro suplementaci dětí a dospívajících vitaminem D. Ces-slov Pediat 2019; 74(8): 473-482.

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.


    Return to the content