JOURNAL OF THE CZECH PEDIATRIC SOCIETY AND THE SLOVAK PEDIATRIC SOCIETY

Čes-slov Pediat 2023, 78(1):48-53 | DOI: 10.55095/CSPediatrie2023/009

Regulation of energy balance and eating behaviourThe epidemic of childhood obesity

Jan Lebl1, Jana Křenek Malíková1, Irena Aldhoon Hainerová2, 3
1 Pediatrická klinika, 2. lékařská fakulta UK a Fakultní nemocnice v Motole, Praha
2 Klinika dětí a dorostu, 3. lékařská fakulta UK a Fakultní nemocnice Královské Vinohrady, Praha
3 Pediatrická klinika, 1. lékařská fakulta UK a Fakultní Thomayerova nemocnice, Praha

Energy balance and eating behaviour are regulated by leptin-melanocortin system that includes afferent signals from peripheral tissues (leptin, ghrelin, insulin, blood glucose), integrative first order neurons in arcuate nucleus, and second order effector neurons in paraventricular and intermediolateral nuclei that express melanocortin receptors. Components of this system have individual genetic a nd epigenetic coding, with partial impact of environmental factors. Abnormal eating behaviour may be due to pathogenic variants of genes encoding key molecules of eating behaviour. Monogenic obesity is characterized by early-onset obesity - in some cases with insulin resistance and/or neurodevelopmental delay.

Keywords: eating behaviour, energy balance, obesity, monogenic obesity, basal thermogenesis, gut microbiome

Published: January 20, 2023  Show citation

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Lebl J, Křenek Malíková J, Aldhoon Hainerová I. Regulation of energy balance and eating behaviour. Ces-slov Pediat. 2023;78(1):48-53. doi: 10.55095/CSPediatrie2023/009.
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