JOURNAL OF THE CZECH PEDIATRIC SOCIETY AND THE SLOVAK PEDIATRIC SOCIETY

Čes-slov Pediat 2022, 77(3):175-179 | DOI: 10.55095/CSPediatrie2022/022

Clinical characteristics of patients with a severe course of acute SARS-CoV-2 infection hospitalised in the Department of Paediatrics, University Hospital MotolOriginal Papers

Jan David, Šárka Pešková, Ledjona Toni, Filip Fencl, Petr Pohunek
Pediatrická klinika 2. lékařské fakulty Univerzity Karlovy a Fakultní nemocnice v Motole, Praha

Objective: Although the SARS-CoV-2 infection (COVID-19) is highly contagious, paediatric patients represent only a small proportion of all diagnosed patients. The aim of this study was to assess the clinical characteristics of patients hospitalised with a serious course of acute SARS-CoV-2 infection at the Department of Paediatrics, University Hospital Motol in Prague, Czech Republic.

Methods: We performed a retrospective observational study based on patients hospitalised with acute SARS-CoV-2 infection who were admitted to our department between 1st January 2020 and 1st April 2021. The anonymised data were obtained by medical record review. Serious course criterion was defined as respiratory failure when at least oxygen therapy was needed.

Results: A total of ten patients were hospitalised in our department during the monitored period. The median age was 15 years (range 2-17), predominantly boys (60%). All patients had associated chronic conditions, the most common (60%) being overweight or obesity.

Conclusion: In our experience, comorbid children, especially ones who are obesity or overweight, are at risk of a serious course of acute SARS-CoV-2 infection. This highlights the importance of vaccination for this part of paediatric population as well.

Keywords: COVID-19, acute infection, children

Published: June 1, 2022  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
David J, Pešková Š, Toni L, Fencl F, Pohunek P. Clinical characteristics of patients with a severe course of acute SARS-CoV-2 infection hospitalised in the Department of Paediatrics, University Hospital Motol. Ces-slov Pediat. 2022;77(3):175-179. doi: 10.55095/CSPediatrie2022/022.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Ludvigsson JF. Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatr 2020; 109(6): 1088-95. Go to original source... Go to PubMed...
    2. Dhochak N, Singhal T, Kabra SK, et al. Pathophysiology of COVID-19: Why children fare better than adults? Indian J Pediatr 2020; 87(7): 537-46. Go to original source... Go to PubMed...
    3. Ni W, Yang X, Yang D, et al. Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19. Crit Care 2020; 24(1): 422. Go to original source... Go to PubMed...
    4. Mihalopoulos M, Levine AC, Marayati NF, et al. The resilient child: sex-steroid hormones and COVID-19 incidence in pediatric patients. J Endocr Soc 2020; 4(9): bvaa106. Go to original source... Go to PubMed...
    5. Mehta NS, Mytton OT, Mullins EWS, et al. SARS-CoV-2 (COVID-19): What do we know about children? A systematic review. Clin Infect Dis 2020; 71(9): 2469-79. Go to original source... Go to PubMed...
    6. Williams N, Radia T, Harman K, et al. COVID-19 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adolescents: a systematic review of critically unwell children and the association with underlying comorbidities. Eur J Pediatr 2021; 180(3): 689-97. Go to original source... Go to PubMed...
    7. Gunes H. What chances do children have against COVID-19? Is the answer hidden within the thymus? Eur J Pediatr 2021; 180(3): 983-6. Go to original source... Go to PubMed...
    8. Yasuhara J, Kuno T, Takagi H, et al. Clinical characteristics of COVID-19 in children: A systematic review. Pediatr Pulmonol 2020; 55(10): 2565-75. Go to original source... Go to PubMed...
    9. Jiehao C, Jing X, Daojiong L, et al. A case series of children with 2019 novel coronavirus infection: clinical and epidemiological features. Clin Infect Dis 2020; 71(6): 1547-51. Go to original source... Go to PubMed...
    10. Dong Y, Mo X, Hu Y, et al. Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China. Pediatrics 2020. doi: 10.1542/peds.2020-0702 Go to original source... Go to PubMed...
    11. Aghagoli G, Gallo Marin B, Katchur NJ, et al. Neurological involvement in COVID-19 and potential mechanisms: a review. Neurocrit Care 2021; 34: 1062-71. Go to original source... Go to PubMed...
    12. Rostad CA, Chahroudi A, Mantus G, et al. Quantitative SARS-CoV-2 serology in children with multisystem inflammatory syndrome (MIS-C). Pediatrics 2020; 146: e2020018242. Go to original source... Go to PubMed...
    13. Whitworth HB, Sartain SE, Kumar R, et al. Rate of thrombosis in children and adolescents hospitalized with COVID-19 or MIS-C. Blood 2021; 5: blood.2020010218. Go to original source... Go to PubMed...
    14. Centers for Disease Control and Prevention: Covid-19 vaccine effectiveness. Dostupné na: https://www.cdc.gov/coronavirus/2019-ncov/vaccines/effectiveness/how-they-work.html

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.


    Return to the content