JOURNAL OF THE CZECH PEDIATRIC SOCIETY AND THE SLOVAK PEDIATRIC SOCIETY

Čes-slov Pediat 2024, 79(1):46-52 | DOI: 10.55095/CSPediatrie2023/055

Chemical pleurodesis with povidone-iodine (Betadine) in congenital chylothorax: personal experience and review of literature

Jiří Náhlovský1, Radek Štichhauer2, Jana Lešková2, Jan Malý1, Tomáš Matějek1
1 Dětská klinika, Lékařská fakulta v Hradci Králové, Univerzita Karlova a Fakultní nemocnice Hradec Králové
2 Klinika dětské chirurgie a traumatologie, Lékařská fakulta v Hradci Králové, Univerzita Karlova a Fakultní nemocnice Hradec Králové

Congenital chylothorax is a serious neonatal condition with high mortality and difficult management. Chemical pleurodesis can limit the need for surgical treatment, but there is no consensus on the optimal chemical agent for the lack of solid evidence. We report our experience with povidone-iodine (PVI) chemical pleurodesis in two neonates with congenital chylothorax. Pleurodesis consisted in the

injection of 2 ml/kg of a 4% povidone iodine solution inside the pleural space, leaving the pleural tube clamped for the subsequent 4 hours. In both cases, repeated doses of povidone-iodine were required to completely stop chyle formation. Based on our experience, chemical pleurodesis with povidone-iodine promptly and definitely stopped pleural effusion, with no side effect observed. Since its fir

st use in 2003, we provide analysis of all published neonatal case reports concerning PVI chemical pleurodesis in congenital chylothorax (n = 20), with both success and survival rate at 80 %.

Keywords: chylothorax, pleurodesis, povidone iodine, newborn, Betadine

Received: July 26, 2023; Revised: October 26, 2023; Accepted: October 27, 2023; Prepublished online: October 30, 2023; Published: January 31, 2024  Show citation

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Náhlovský J, Štichhauer R, Lešková J, Malý J, Matějek T. Chemical pleurodesis with povidone-iodine (Betadine) in congenital chylothorax: personal experience and review of literature. Ces-slov Pediat. 2024;79(1):46-52. doi: 10.55095/CSPediatrie2023/055.
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