JOURNAL OF THE CZECH PEDIATRIC SOCIETY AND THE SLOVAK PEDIATRIC SOCIETY

Čes-slov Pediat 2023, 78(90):5-10 | DOI: 10.55095/CSPediatrie2023/056

Current view on the diagnostics of growth hormone deficiency in childhood and adolescenceComprehensive Report

Lukáš Plachý, Klára Maratová, Karolína Veselá, Jan Lebl, Štěpánka Průhová
Pediatrická klinika, 2. lékařská fakulta, Univerzita Karlova a FN Motol, Praha

Optimal growth hormone (GH) production, secretion and function are essential for physiological human growth. Relevant assessment of growth hormone deficiency (GHD) is crucial for an early initiation of GH substitution aiming to improve body height and to prevent hypoglycemia and other consequences of GHD. However, even 60 years after the launch of first GH laboratory assay, diagnosis of GHD still

faces technical and interpretational problems. GH stimulation tests are considered the golden standard to diagnose GHD, however their specificity is low, and therefore frequently generating false pathologic results. Therefore, diagnosis of GHD requires a

complex evaluation of the patient history and auxological data on the background of stimulation testes, IGF-1 level, and of imaging methods and g

enetic testing in selected cases.

Keywords: short stature, growth hormone, growth hormone deficiency

Accepted: November 22, 2023; Published: January 31, 2024  Show citation

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Plachý L, Maratová K, Veselá K, Lebl J, Průhová Š. Current view on the diagnostics of growth hormone deficiency in childhood and adolescence. Ces-slov Pediat. 2023;78(Suppl.3):5-10. doi: 10.55095/CSPediatrie2023/056.
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