JOURNAL OF THE CZECH PEDIATRIC SOCIETY AND THE SLOVAK PEDIATRIC SOCIETY

Čes-slov Pediat 2023, 78(3):176-181 | DOI: 10.55095/CSPediatrie2023/024

GLP-1 analogues in therapy of obese adolescents. Early real-life experience with liraglutide treatmentThe epidemic of childhood obesity

Jana Křenek Malíková, Jan Lebl
Pediatrická klinika 2. lékařské fakulty Univerzity Karlovy a Fakultní nemocnice v Motole, Praha

The GLP-1 analog liraglutide is registered for pharmacotherapy of obese adolescents aged 12-17 years since 2021. According to clinical studies, liraglutide administration leads to a mean weight loss 4.6%. We summarize early real-life experience with this novel therapy.

Nine boys were treated with liraglutide under the supervision of out-patient clinic for obesity of Department of Pediatrics, University Hospital Motol between September 2021 and January 2023. At treatment onset, they were 12.0-16.5 years old (median 15), and had body weight 74-188 Kg (median 123) and BMI 30.7-65.9 Kg/m2

(median 38.6). Therapy was initiated following failure of conventional treatment including psychological intervention. After the early-phase dose escalation, the long-term daily treatment dose stabilized at 1.8-3.0 mg (median 2.4). Therapy was accompanied by nutritional and behavioral intervention. Following 4-15 months on therapy (median 6), BMI declined to 31.5-61.6 Kg/m2

(median 35.6; p

Keywords: obesity, adolescence, pharmacotherapy, GLP-1 analogs, liraglutide

Accepted: June 22, 2023; Published: June 23, 2023  Show citation

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Křenek Malíková J, Lebl J. GLP-1 analogues in therapy of obese adolescents. Early real-life experience with liraglutide treatment. Ces-slov Pediat. 2023;78(3):176-181. doi: 10.55095/CSPediatrie2023/024.
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